2014 WHO Clinical Molecular and Pathological (WHO-CMP) Diagnostic Criteria for the Classification and Staging of Five Distinct JAK2, MPL and CALR Mutated Myeloproliferative Neoplasms
نویسندگان
چکیده
Jan Jacques Michiels1*, Karel Forstier2, Fransje Valster3, Vincent Potters3, Katrien Schelfout3 and Hendrik De Raeve4,5 1International Collaboration and Research on Myeloproliferative Neoplasms: ICAR. MPN, Goodheart Insititute in Nature Medicine and Health, The Netherlands 2Department of Hematology, Rotterdam, The Netherlands 3Department of Internal Medicine, University Hospital Brussels, Belgium 4Departments of Pathology, Lievensberg Hospital Bergen op Zoom, OLV Hospital Aalst, The Netherlands 5Departments of Pathology, University Hospital Brussels, Belgium
منابع مشابه
Coexisting JAK2V617F and CALR Exon 9 Mutations in Myeloproliferative Neoplasms - Do They Designate a New Subtype?
The classic BCR-ABL1-negative myeloproliferative neoplasm is an operational sub-category of MPNs that includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The JAK2V617F mutation is found in ~ 95% of PV and 50-60% of ET or PMF. In most of the remaining JAK2V617F- negative PV cases, JAK2 exon 12 mutations are present. Amongst the JAK2V617F-negative ET ...
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